Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia

Uri Zilberman; Patricia Smith

doi:doi:10.11648/j.ija.20221002.13

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Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia

Uri Zilberman, Patricia Smith

Published in International Journal of Archaeology (Volume 10, Issue 2)

Received: 27 November 2022 Accepted: 14 December 2022 Published: 23 December 2022

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Abstract

Background: Recently, Le Cabec et al. (2021) contested the identification of Zilberman et al. (2004), of Amelogenesis Imperfecta (AI) Type II/III in the Garba IVE Homo erectus child hemi-mandible and attributed the lack of contrast between enamel and dentin in this specimen to a unique form of diagenesis. Objectives: To assess the basis for their conclusions in view of the fact that the Le Cabec et al. (2021) study relates to a genetically and clinically distinct condition - Hypoplastic AI, and does not relate to the Type II/III AI syndrome th.at Zilberman et al. described. Method: The authors analyzed the Le Cabec et al. article and compared their findings with the radiological and clinical findings in Amelogenesis Imperfecta Type II/III. Results: Le Cabec et al. (2021) presented detailed scans and synchotron study that replicate and support the findings of Zilberman et al. (2004); in showing lack of differentiation between enamel and dentin - typical of Amelogenesis Imperfecta Type II/III condition - together with excellent preservation of enamel micromorphology and clearly defined pulp chambers and pulp canals. Moreover, chemical corrosion results in loss of tissue whereas there is no evidence of this in Garba IVE. Conclusion: The authors contend that the findings in Le Cabec et al. (2021) are characteristic features of Type II/III AI as initially diagnosed by Zilberman et al. (2004), and best account for the similarity seen in radio-opacity of enamel and dentin.

Published in	International Journal of Archaeology (Volume 10, Issue 2)
DOI	10.11648/j.ija.20221002.13
Page(s)	46-50
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fossil Teeth, Mineralization, Enamel Formation, Mutations, Dental Pathology, Diagenesis

References

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[4]	Zhang, C., Song, Y., Bian, Z. Ultrastructural analysis of the teeth affected by amelogenesis imperfecta resulting from FAM83H mutations and review of the literature. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 119, e69-e76 (2015).
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[7]	Nikolopoulos G, Smith C. E. L., Poulter J. A., et al. Spectrum of pathogenic variants and founder effects in amelogenesis imperfecta associated with MMP20. Hum. Mutat. 42, 567-576 (2021). doi: 10.1002/humu.24187.
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[15]	Le Cabec, A. et al. Insights into the palaeobiology of an early Homo infant: multidisciplinary investigation of the GAR IVE hemimandible, Melka Kunture, Ethiopia. Sci. Rep. 29, 11, 23087, doi: 10.1038/s41598-021-02462-1 (2021).
[16]	Husein, D., Alamoudi, A., Ohyama, Y. et al. Identification of the C-terminal region in Amelogenesis Imperfecta causative protein WDR72 required for Golgi localization. Sci Rep 12, 4640 (2022). https://doi.org/10.1038/s41598-022-08719-7
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APA Style

Uri Zilberman, Patricia Smith. (2022). Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia. International Journal of Archaeology, 10(2), 46-50. https://doi.org/10.11648/j.ija.20221002.13

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ACS Style

Uri Zilberman; Patricia Smith. Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia. Int. J. Archaeol. 2022, 10(2), 46-50. doi: 10.11648/j.ija.20221002.13

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AMA Style

Uri Zilberman, Patricia Smith. Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia. Int J Archaeol. 2022;10(2):46-50. doi: 10.11648/j.ija.20221002.13

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@article{10.11648/j.ija.20221002.13,
  author = {Uri Zilberman and Patricia Smith},
  title = {Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia},
  journal = {International Journal of Archaeology},
  volume = {10},
  number = {2},
  pages = {46-50},
  doi = {10.11648/j.ija.20221002.13},
  url = {https://doi.org/10.11648/j.ija.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ija.20221002.13},
  abstract = {Background: Recently, Le Cabec et al. (2021) contested the identification of Zilberman et al. (2004), of Amelogenesis Imperfecta (AI) Type II/III in the Garba IVE Homo erectus child hemi-mandible and attributed the lack of contrast between enamel and dentin in this specimen to a unique form of diagenesis. Objectives: To assess the basis for their conclusions in view of the fact that the Le Cabec et al. (2021) study relates to a genetically and clinically distinct condition - Hypoplastic AI, and does not relate to the Type II/III AI syndrome th.at Zilberman et al. described. Method: The authors analyzed the Le Cabec et al. article and compared their findings with the radiological and clinical findings in Amelogenesis Imperfecta Type II/III. Results: Le Cabec et al. (2021) presented detailed scans and synchotron study that replicate and support the findings of Zilberman et al. (2004); in showing lack of differentiation between enamel and dentin - typical of Amelogenesis Imperfecta Type II/III condition - together with excellent preservation of enamel micromorphology and clearly defined pulp chambers and pulp canals. Moreover, chemical corrosion results in loss of tissue whereas there is no evidence of this in Garba IVE. Conclusion: The authors contend that the findings in Le Cabec et al. (2021) are characteristic features of Type II/III AI as initially diagnosed by Zilberman et al. (2004), and best account for the similarity seen in radio-opacity of enamel and dentin.},
 year = {2022}
}

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TY - JOUR
T1 - Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia
AU - Uri Zilberman
AU - Patricia Smith
Y1 - 2022/12/23
PY - 2022
N1 - https://doi.org/10.11648/j.ija.20221002.13
DO - 10.11648/j.ija.20221002.13
T2 - International Journal of Archaeology
JF - International Journal of Archaeology
JO - International Journal of Archaeology
SP - 46
EP - 50
PB - Science Publishing Group
SN - 2330-7595
UR - https://doi.org/10.11648/j.ija.20221002.13
AB - Background: Recently, Le Cabec et al. (2021) contested the identification of Zilberman et al. (2004), of Amelogenesis Imperfecta (AI) Type II/III in the Garba IVE Homo erectus child hemi-mandible and attributed the lack of contrast between enamel and dentin in this specimen to a unique form of diagenesis. Objectives: To assess the basis for their conclusions in view of the fact that the Le Cabec et al. (2021) study relates to a genetically and clinically distinct condition - Hypoplastic AI, and does not relate to the Type II/III AI syndrome th.at Zilberman et al. described. Method: The authors analyzed the Le Cabec et al. article and compared their findings with the radiological and clinical findings in Amelogenesis Imperfecta Type II/III. Results: Le Cabec et al. (2021) presented detailed scans and synchotron study that replicate and support the findings of Zilberman et al. (2004); in showing lack of differentiation between enamel and dentin - typical of Amelogenesis Imperfecta Type II/III condition - together with excellent preservation of enamel micromorphology and clearly defined pulp chambers and pulp canals. Moreover, chemical corrosion results in loss of tissue whereas there is no evidence of this in Garba IVE. Conclusion: The authors contend that the findings in Le Cabec et al. (2021) are characteristic features of Type II/III AI as initially diagnosed by Zilberman et al. (2004), and best account for the similarity seen in radio-opacity of enamel and dentin.
VL - 10
IS - 2
ER -

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Author Information

Uri Zilberman

Pediatric Dental Clinic, Barzilai Medical University Center, Ashkelon, Israel
Patricia Smith

Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

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APA Style

Uri Zilberman, Patricia Smith. (2022). Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia. International Journal of Archaeology, 10(2), 46-50. https://doi.org/10.11648/j.ija.20221002.13

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ACS Style

Uri Zilberman; Patricia Smith. Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia. Int. J. Archaeol. 2022, 10(2), 46-50. doi: 10.11648/j.ija.20221002.13

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AMA Style

Uri Zilberman, Patricia Smith. Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia. Int J Archaeol. 2022;10(2):46-50. doi: 10.11648/j.ija.20221002.13

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@article{10.11648/j.ija.20221002.13,
  author = {Uri Zilberman and Patricia Smith},
  title = {Pros and Cons of Amelogenesis Imperfecta in the GARBA IV Hemi-Mandible, Melka Kunture, Ethiopia},
  journal = {International Journal of Archaeology},
  volume = {10},
  number = {2},
  pages = {46-50},
  doi = {10.11648/j.ija.20221002.13},
  url = {https://doi.org/10.11648/j.ija.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ija.20221002.13},
  abstract = {Background: Recently, Le Cabec et al. (2021) contested the identification of Zilberman et al. (2004), of Amelogenesis Imperfecta (AI) Type II/III in the Garba IVE Homo erectus child hemi-mandible and attributed the lack of contrast between enamel and dentin in this specimen to a unique form of diagenesis. Objectives: To assess the basis for their conclusions in view of the fact that the Le Cabec et al. (2021) study relates to a genetically and clinically distinct condition - Hypoplastic AI, and does not relate to the Type II/III AI syndrome th.at Zilberman et al. described. Method: The authors analyzed the Le Cabec et al. article and compared their findings with the radiological and clinical findings in Amelogenesis Imperfecta Type II/III. Results: Le Cabec et al. (2021) presented detailed scans and synchotron study that replicate and support the findings of Zilberman et al. (2004); in showing lack of differentiation between enamel and dentin - typical of Amelogenesis Imperfecta Type II/III condition - together with excellent preservation of enamel micromorphology and clearly defined pulp chambers and pulp canals. Moreover, chemical corrosion results in loss of tissue whereas there is no evidence of this in Garba IVE. Conclusion: The authors contend that the findings in Le Cabec et al. (2021) are characteristic features of Type II/III AI as initially diagnosed by Zilberman et al. (2004), and best account for the similarity seen in radio-opacity of enamel and dentin.},
 year = {2022}
}

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